Red Dead Redemption 2

You need to pass these launch options to even run the game:

WINEDLLOVERRIDES="vulkan-1=b" %command% -vulkan -ignorepipelinecache

While it works pretty fine, I had to not only put everything on the lowest settings, but also modify system.xml, as you will most of the time pass the VRAM limit in the settings, which does not allow you to modify them inside the game itself. With all this, at 720p and with FSR set at performance, you get a reasonably stable 30 FPS (only if you limit the framerate from the headset itself, otherwise it gets jittery.). Keep in mind, the first Chapter, in the snow, will have the game take a hit and run at about 26 FPS on average, but if you go through this it should be more playable. The bemchmark puts the game at 29.788 FPS average, with 5.356 FPS lows and a max of 53.217 FPS.